Expression of CLPS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Colipase, pancreatic

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA010512

GENE INFORMATION
Gene name	CLPS
Synonyms
Description	Colipase, pancreatic (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	35794982 - 35797344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137392 (version 83.38)
Entrez gene	1208
UniProt	P04118 (UniProt - Evidence at protein level)
neXtProt	NX_P04118
Antibodypedia	CLPS antibodies

PROTEIN BROWSER

CLPS-001	CLPS-201	CLPS-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLPS-001 ENSP00000259938 ENST00000259938	P04118 [Direct mapping] Colipase Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0007586 [digestion] GO:0007603 [phototransduction, visible light] GO:0008047 [enzyme activator activity] GO:0009791 [post-embryonic development] GO:0016042 [lipid catabolic process] GO:0032094 [response to food] GO:0043085 [positive regulation of catalytic activity] GO:0044241 [lipid digestion] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	112 aa 12 kDa	Yes	0
CLPS-201 ENSP00000483589 ENST00000616014	A0A087X0Q7 [Direct mapping] Colipase; Colipase, pancreatic, isoform CRA_b Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0007586 [digestion] GO:0008047 [enzyme activator activity] GO:0016042 [lipid catabolic process] GO:0043085 [positive regulation of catalytic activity] Show all	71 aa 7.7 kDa	Yes	0
CLPS-202 ENSP00000482919 ENST00000622413	A0A087WZW1 [Direct mapping] Colipase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0007586 [digestion] GO:0008047 [enzyme activator activity] GO:0016042 [lipid catabolic process] GO:0043085 [positive regulation of catalytic activity] Show all	98 aa 10.6 kDa	No	0