Cell atlas - NRM - The Human Protein Atlas

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NRM

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane

Human cell
	Nuclear membrane

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GENERAL INFORMATION
Gene name	NRM
Gene description	Nurim (nuclear envelope membrane protein)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA072545 , HPA073982
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane.

Main location

Nuclear membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072545	HaCaT	Nuclear membrane
	HPA072545	U-2 OS	Nuclear membrane
	HPA072545	U-251 MG	Nuclear membrane
	HPA073982	RH-30	Nuclear membrane
	HPA073982	U-2 OS	No staining

GENE INFORMATION
Gene name	NRM (HGNC Symbol)
Synonyms	NRM29
Description	Nurim (nuclear envelope membrane protein) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	30688047 - 30691420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137404 (version 83.38)
Entrez gene	11270
UniProt	Q8IXM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXM6
Antibodypedia	NRM antibodies

PROTEIN BROWSER

NRM-001	NRM-005	NRM-007	NRM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRM-001 ENSP00000259953 ENST00000259953	Q8IXM6 [Direct mapping] Nurim Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	262 aa 29.4 kDa	Yes	5
NRM-005 ENSP00000365602 ENST00000376420	Q8IXM6 [Direct mapping] Nurim Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	203 aa 22.4 kDa	Yes	3
NRM-007 ENSP00000397892 ENST00000444096	H0Y6T6 [Direct mapping] Nurim Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	262 aa 29.5 kDa	No	5
NRM-201 ENSP00000365603 ENST00000376421	Q8IXM6 [Direct mapping] Nurim Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	262 aa 29.4 kDa	Yes	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.