Expression of SLCO2B1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier organic anion transporter family, member 2B1

Protein class

FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA020659

GENE INFORMATION
Gene name	SLCO2B1 (HGNC Symbol)
Synonyms	OATP-B, OATP2B1, SLC21A9
Description	Solute carrier organic anion transporter family, member 2B1 (HGNC Symbol)
Entrez gene summary	This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	75100563 - 75206549
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137491 (version 83.38)
Entrez gene	11309
UniProt	O94956 (UniProt - Evidence at protein level)
neXtProt	NX_O94956
Antibodypedia	SLCO2B1 antibodies

PROTEIN BROWSER

SLCO2B1-001	SLCO2B1-002	SLCO2B1-003	SLCO2B1-005	SLCO2B1-006	SLCO2B1-007	SLCO2B1-008	SLCO2B1-009	SLCO2B1-010	SLCO2B1-015	SLCO2B1-016	SLCO2B1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLCO2B1-001 ENSP00000289575 ENST00000289575	A0A024R5I4 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0006810 [transport] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0071718 [sodium-independent icosanoid transport] Show all	709 aa 76.7 kDa	No	>9
SLCO2B1-002 ENSP00000436324 ENST00000525650	A0A0A0MTF1 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	565 aa 61.2 kDa	No	9
SLCO2B1-003 ENSP00000434112 ENST00000532236	E9PRW4 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	593 aa 64.2 kDa	Yes	9
SLCO2B1-005 ENSP00000388912 ENST00000428359	O94956 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	687 aa 74.4 kDa	No	>9
SLCO2B1-006 ENSP00000389653 ENST00000454962	O94956 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	482 aa 52.5 kDa	No	7
SLCO2B1-007 ENSP00000435384 ENST00000530556	C7BWB6 [Direct mapping] Solute carrier organic anion transporter family member 2B1; Solute carrier organic anion transporter family, member 2B1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 4.8 kDa	No	0
SLCO2B1-008 ENSP00000431192 ENST00000534004	C7BWB6 [Direct mapping] Solute carrier organic anion transporter family member 2B1; Solute carrier organic anion transporter family, member 2B1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 4.8 kDa	No	0
SLCO2B1-009 ENSP00000431324 ENST00000525845	C7BWB6 [Direct mapping] Solute carrier organic anion transporter family member 2B1; Solute carrier organic anion transporter family, member 2B1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 4.8 kDa	No	0
SLCO2B1-010 ENSP00000432889 ENST00000531713	E9PN87 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] Show all	87 aa 9.3 kDa	No	0
SLCO2B1-015 ENSP00000433872 ENST00000534186	E9PIU9 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	127 aa 13.8 kDa	No	2
SLCO2B1-016 ENSP00000436513 ENST00000527180	E9PI53 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	150 aa 16.2 kDa	No	2
SLCO2B1-019 ENSP00000434742 ENST00000526839	H0YE11 [Direct mapping] Solute carrier organic anion transporter family member 2B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	147 aa 15.8 kDa	No	2