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NUMA1

GENERAL INFORMATION

Gene name

 NUMA1

Gene description

 Nuclear mitotic apparatus protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 23
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA019841 , HPA019859 , HPA029912
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NUMA1

Synonyms

Description

 Nuclear mitotic apparatus protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 72002864 - 72080693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137497 (version 83.38)

Entrez gene

 4926

UniProt

 Q14980 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14980

Antibodypedia

 NUMA1 antibodies

PROTEIN BROWSER
«
NUMA1-001
NUMA1-002
NUMA1-005
NUMA1-006
NUMA1-009
NUMA1-012
NUMA1-014
NUMA1-015
NUMA1-017
NUMA1-018
NUMA1-019
NUMA1-020
NUMA1-021
NUMA1-022
NUMA1-023
NUMA1-024
NUMA1-025
NUMA1-026
NUMA1-027
NUMA1-028
NUMA1-201
NUMA1-202
NUMA1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUMA1-001
ENSP00000377298
ENST00000393695
Q14980 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005938 [cell cortex]
GO:0006997 [nucleus organization]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0016363 [nuclear matrix]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
GO:0045177 [apical part of cell]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0060487 [lung epithelial cell differentiation]
GO:0070062 [extracellular exosome]
GO:0097431 [mitotic spindle pole]
Show all
 2115 aa
238.3 kDa 		No 0
NUMA1-002
ENSP00000351851
ENST00000358965
Q14980 [Direct mapping]
Nuclear mitotic apparatus protein 1
A0A024R5M9 [Target identity:100%; Query identity:100%]
Nuclear mitotic apparatus protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005938 [cell cortex]
GO:0006997 [nucleus organization]
GO:0007067 [mitotic nuclear division]
GO:0016363 [nuclear matrix]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0097431 [mitotic spindle pole]
Show all
 2101 aa
236.5 kDa 		No 0
NUMA1-005
ENSP00000442936
ENST00000537217
F5H6Y5 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 691 aa
78.3 kDa 		No 0
NUMA1-006
ENSP00000260051
ENST00000351960
Q14980 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005938 [cell cortex]
GO:0006997 [nucleus organization]
GO:0007067 [mitotic nuclear division]
GO:0016363 [nuclear matrix]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0097431 [mitotic spindle pole]
Show all
 979 aa
109.3 kDa 		No 0
NUMA1-009
ENSP00000444880
ENST00000542977
F5H4J1 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 852 aa
97.1 kDa 		No 0
NUMA1-012
ENSP00000440954
ENST00000541584
H0YFY6 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 964 aa
107.3 kDa 		No 0
NUMA1-014
ENSP00000441598
ENST00000541641
F5GWK2 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
8.1 kDa 		No 0
NUMA1-015
ENSP00000439759
ENST00000543937
F5H0Z7 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 201 aa
22.5 kDa 		No 0
NUMA1-017
ENSP00000357955
ENST00000368959
F8W6T3 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 91 aa
10.1 kDa 		No 0
NUMA1-018
ENSP00000442331
ENST00000546131
F5H7R5 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
6.2 kDa 		No 0
NUMA1-019
ENSP00000441674
ENST00000535111
F5GWA2 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.8 kDa 		No 0
NUMA1-020
ENSP00000438331
ENST00000541719
F5H068 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 83 aa
9.3 kDa 		No 0
NUMA1-021
ENSP00000438318
ENST00000366394
F5H073 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 75 aa
8.5 kDa 		No 0
NUMA1-022
ENSP00000444831
ENST00000535838
F5H4Y4 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.5 kDa 		No 0
NUMA1-023
ENSP00000439576
ENST00000535087
F5H1L0 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 109 aa
12.2 kDa 		No 0
NUMA1-024
ENSP00000438821
ENST00000543009
F5H3L6 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 174 aa
19.6 kDa 		No 0
NUMA1-025
ENSP00000438589
ENST00000537930
F5H2F3 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 159 aa
18 kDa 		No 0
NUMA1-026
ENSP00000442761
ENST00000544238
F5H763 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 220 aa
24.7 kDa 		No 0
NUMA1-027
ENSP00000444175
ENST00000535947
F5GZW1 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 146 aa
16.6 kDa 		No 0
NUMA1-028
ENSP00000439092
ENST00000544129
F5H2F3 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 159 aa
18 kDa 		No 0
NUMA1-201
ENSP00000480172
ENST00000613205
Q14980 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005938 [cell cortex]
GO:0006997 [nucleus organization]
GO:0007067 [mitotic nuclear division]
GO:0016363 [nuclear matrix]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0097431 [mitotic spindle pole]
Show all
 979 aa
109.3 kDa 		No 0
NUMA1-202
ENSP00000481541
ENST00000616538
A0A087WY61 [Direct mapping]
Nuclear mitotic apparatus protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
Show all
 2099 aa
236.2 kDa 		No 0
NUMA1-203
ENSP00000478624
ENST00000620566
Q14980 [Direct mapping]
Nuclear mitotic apparatus protein 1
A0A024R5M9 [Target identity:100%; Query identity:100%]
Nuclear mitotic apparatus protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005938 [cell cortex]
GO:0006997 [nucleus organization]
GO:0007067 [mitotic nuclear division]
GO:0016363 [nuclear matrix]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0097431 [mitotic spindle pole]
Show all
 2101 aa
236.5 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.