Expression of PRCP in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Prolylcarboxypeptidase (angiotensinase C)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017065

GENE INFORMATION
Gene name	PRCP (HGNC Symbol)
Synonyms	HUMPCP, PCP
Description	Prolylcarboxypeptidase (angiotensinase C) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	82823502 - 82970584
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137509 (version 83.38)
Entrez gene	5547
UniProt	P42785 (UniProt - Evidence at protein level)
neXtProt	NX_P42785
Antibodypedia	PRCP antibodies

PROTEIN BROWSER

PRCP-001	PRCP-002	PRCP-005	PRCP-006	PRCP-007	PRCP-008	PRCP-009	PRCP-010	PRCP-011	PRCP-012	PRCP-013	PRCP-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRCP-001 ENSP00000317362 ENST00000313010	P42785 [Direct mapping] Lysosomal Pro-X carboxypeptidase A0A024R5L0 [Target identity:100%; Query identity:100%] Prolylcarboxypeptidase (Angiotensinase C), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008236 [serine-type peptidase activity] GO:0070062 [extracellular exosome] Show all	496 aa 55.8 kDa	Yes	0
PRCP-002 ENSP00000377055 ENST00000393399	P42785 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002155 [regulation of thyroid hormone mediated signaling pathway] GO:0002353 [plasma kallikrein-kinin cascade] GO:0003085 [negative regulation of systemic arterial blood pressure] GO:0004185 [serine-type carboxypeptidase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008236 [serine-type peptidase activity] GO:0042593 [glucose homeostasis] GO:0045178 [basal part of cell] GO:0060055 [angiogenesis involved in wound healing] GO:0070062 [extracellular exosome] GO:0097009 [energy homeostasis] GO:2000377 [regulation of reactive oxygen species metabolic process] Show all	517 aa 58.1 kDa	Yes	0
PRCP-005 ENSP00000436141 ENST00000527444	E9PQN3 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	183 aa 20.5 kDa	No	0
PRCP-006 ENSP00000431435 ENST00000531128	E9PL85 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	148 aa 16.5 kDa	No	0
PRCP-007 ENSP00000432004 ENST00000531801	E9PIG4 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	234 aa 26.4 kDa	No	0
PRCP-008 ENSP00000431559 ENST00000534631	E9PKN6 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	192 aa 21.6 kDa	No	0
PRCP-009 ENSP00000431496 ENST00000533126	E9PL49 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	43 aa 5.1 kDa	No	0
PRCP-010 ENSP00000435071 ENST00000528082	E9PLY4 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	100 aa 11.1 kDa	No	0
PRCP-011 ENSP00000434771 ENST00000529671	E9PNJ1 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	164 aa 18.6 kDa	No	0
PRCP-012 ENSP00000437169 ENST00000532809	E9PNF7 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	116 aa 13.5 kDa	No	0
PRCP-013 ENSP00000436095 ENST00000534264	E9PR42 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	26 aa 3.1 kDa	No	0
PRCP-019 ENSP00000432506 ENST00000534396	E9PQB5 [Direct mapping] Lysosomal Pro-X carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	145 aa 16.3 kDa	No	0