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Malignant tissues generally exhibited cytoplasmic staining of varying intensity, often in a granular pattern. Strong staining was seen in most prostate cancers and several cases of endometrial, ovarian and breast cancers. Malignant lymphoma, melanoma as well as skin and testicular cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PI15 (HGNC Symbol)
Synonyms
P25TI
Description
Peptidase inhibitor 15 (HGNC Symbol)
Entrez gene summary
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)