Expression of GGH in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

Protein class

Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA025226	CAB019296

GENE INFORMATION
Gene name	GGH
Synonyms
Description	Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (HGNC Symbol)
Entrez gene summary	This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	63015079 - 63039171
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137563 (version 83.38)
Entrez gene	8836
UniProt	Q92820 (UniProt - Evidence at protein level)
neXtProt	NX_Q92820
Antibodypedia	GGH antibodies

PROTEIN BROWSER

GGH-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGH-001 ENSP00000260118 ENST00000260118	Q92820 [Direct mapping] Gamma-glutamyl hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005773 [vacuole] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006541 [glutamine metabolic process] GO:0008238 [exopeptidase activity] GO:0008242 [omega peptidase activity] GO:0010043 [response to zinc ion] GO:0016787 [hydrolase activity] GO:0032868 [response to insulin] GO:0034722 [gamma-glutamyl-peptidase activity] GO:0042470 [melanosome] GO:0042493 [response to drug] GO:0045471 [response to ethanol] GO:0046900 [tetrahydrofolylpolyglutamate metabolic process] GO:0070062 [extracellular exosome] Show all	318 aa 36 kDa	Yes	0