Expression of TMPRSS4 in cancer - Summary

CANCER ATLAS

Gene description

Transmembrane protease, serine 4

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006238

GENE INFORMATION
Gene name	TMPRSS4 (HGNC Symbol)
Synonyms	MT-SP2, TMPRSS3
Description	Transmembrane protease, serine 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118077012 - 118121890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137648 (version 83.38)
Entrez gene	56649
UniProt	Q9NRS4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRS4
Antibodypedia	TMPRSS4 antibodies

PROTEIN BROWSER

TMPRSS4-001	TMPRSS4-004	TMPRSS4-005	TMPRSS4-006	TMPRSS4-008	TMPRSS4-011	TMPRSS4-015	TMPRSS4-017	TMPRSS4-201	TMPRSS4-202	TMPRSS4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPRSS4-001 ENSP00000435184 ENST00000534111	Q9NRS4 [Direct mapping] Transmembrane protease serine 4 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	435 aa 48 kDa	No	1
TMPRSS4-004 ENSP00000416037 ENST00000437212	Q9NRS4 [Direct mapping] Transmembrane protease serine 4 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	437 aa 48.2 kDa	No	1
TMPRSS4-005 ENSP00000428814 ENST00000522307	E7ESG9 [Direct mapping] Transmembrane protease serine 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	290 aa 31.8 kDa	No	0
TMPRSS4-006 ENSP00000429209 ENST00000523251	Q9NRS4 [Direct mapping] Transmembrane protease serine 4 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	397 aa 43.8 kDa	No	0
TMPRSS4-008 ENSP00000430547 ENST00000522824	Q9NRS4 [Direct mapping] Transmembrane protease serine 4 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	432 aa 47.7 kDa	No	1
TMPRSS4-011 ENSP00000428407 ENST00000522151	E5RIH1 [Direct mapping] Transmembrane protease serine 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	173 aa 19.1 kDa	No	1
TMPRSS4-015 ENSP00000429833 ENST00000517544	H0YBM5 [Direct mapping] Transmembrane protease serine 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	148 aa 16.3 kDa	No	1
TMPRSS4-017 ENSP00000428246 ENST00000524218	H0YAX8 [Direct mapping] Transmembrane protease serine 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7 kDa	No	0
TMPRSS4-201 ENSP00000480370 ENST00000610964	A0A087WWN4 [Direct mapping] Transmembrane protease serine 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	422 aa 46.5 kDa	No	1
TMPRSS4-202 ENSP00000478147 ENST00000616579	A0A087WTU6 [Direct mapping] Transmembrane protease serine 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	399 aa 44 kDa	No	0
TMPRSS4-203 ENSP00000477949 ENST00000618855	Q9NRS4 [Direct mapping] Transmembrane protease serine 4 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	437 aa 48.2 kDa	No	1