Fields »
ABOUT
HELP
BLOG
TRPC6

CANCER ATLAS

Gene description

 Transient receptor potential cation channel, subfamily C, member 6

Protein class

 Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045098

GENE INFORMATION

Gene name

 TRPC6 (HGNC Symbol)

Synonyms

 FSGS2, TRP6

Description

 Transient receptor potential cation channel, subfamily C, member 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

Chromosome

 11

Cytoband

 q22.1

Chromosome location (bp)

 101451564 - 101872562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137672 (version 83.38)

Entrez gene

 7225

UniProt

 Q9Y210 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y210

Antibodypedia

 TRPC6 antibodies

PROTEIN BROWSER
TRPC6-001
TRPC6-002
TRPC6-003
TRPC6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPC6-001
ENSP00000340913
ENST00000344327
Q9Y210 [Direct mapping]
Short transient receptor potential channel 6
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006828 [manganese ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0030182 [neuron differentiation]
GO:0030276 [clathrin binding]
GO:0032414 [positive regulation of ion transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0036057 [slit diaphragm]
GO:0042805 [actinin binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0050774 [negative regulation of dendrite morphogenesis]
GO:0051117 [ATPase binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
GO:0071456 [cellular response to hypoxia]
Show all
 931 aa
106.3 kDa 		No 8
TRPC6-002
ENSP00000343672
ENST00000348423
Q9Y210 [Direct mapping]
Short transient receptor potential channel 6
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0032414 [positive regulation of ion transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 815 aa
93.2 kDa 		No 7
TRPC6-003
ENSP00000353687
ENST00000360497
Q9Y210 [Direct mapping]
Short transient receptor potential channel 6
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0032414 [positive regulation of ion transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 876 aa
100.1 kDa 		No 7
TRPC6-004
ENSP00000435574
ENST00000532133
E9PJN4 [Direct mapping]
Short transient receptor potential channel 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006828 [manganese ion transport]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 853 aa
97.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.