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POU2F3

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GENERAL INFORMATION

Gene name

 POU2F3

Gene description

 POU class 2 homeobox 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (T-47d, CAPAN-2, SK-BR-3)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, CAPAN-2, SK-BR-3)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 POU2F3 (HGNC Symbol)

Synonyms

 Epoc-1, OCT11, PLA-1, Skn-1a

Description

 POU class 2 homeobox 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 120236640 - 120319944

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137709 (version 83.38)

Entrez gene

 25833

UniProt

 Q9UKI9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UKI9

Antibodypedia

 POU2F3 antibodies

PROTEIN BROWSER
POU2F3-001
POU2F3-005
POU2F3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU2F3-001
ENSP00000441687
ENST00000543440
Q9UKI9 [Direct mapping]
POU domain, class 2, transcription factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008544 [epidermis development]
GO:0043565 [sequence-specific DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 436 aa
47.4 kDa 		No 0
POU2F3-005
ENSP00000453150
ENST00000532663
H0YLC5 [Direct mapping]
POU domain, class 2, transcription factor 3
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 161 aa
17 kDa 		No 0
POU2F3-006
ENSP00000260264
ENST00000260264
Q9UKI9 [Direct mapping]
POU domain, class 2, transcription factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008544 [epidermis development]
GO:0030216 [keratinocyte differentiation]
GO:0042060 [wound healing]
GO:0043565 [sequence-specific DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 438 aa
47.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.