Tissue expression of FXYD6 - Summary - The Human Protein Atlas

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FXYD6

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FXYD6
Gene description	FXYD domain containing ion transport regulator 6
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041334
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FXYD6
Synonyms
Description	FXYD domain containing ion transport regulator 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117836976 - 117877486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137726 (version 83.38)
Entrez gene	53826
UniProt	Q9H0Q3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0Q3
Antibodypedia	FXYD6 antibodies

PROTEIN BROWSER

FXYD6-001	FXYD6-002	FXYD6-003	FXYD6-005	FXYD6-010	FXYD6-017	FXYD6-018	FXYD6-019	FXYD6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FXYD6-001 ENSP00000431446 ENST00000527717	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1
FXYD6-002 ENSP00000433312 ENST00000526014	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1
FXYD6-003 ENSP00000260282 ENST00000260282	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1
FXYD6-005 ENSP00000431427 ENST00000524656	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1
FXYD6-010 ENSP00000436629 ENST00000529335	E9PHZ3 [Direct mapping] FXYD domain-containing ion transport regulator 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	111 aa 12.5 kDa	Yes	1
FXYD6-017 ENSP00000463160 ENST00000584394	J3QKN1 [Direct mapping] FXYD domain containing ion transport regulator 6, isoform CRA_b; FXYD domain-containing ion transport regulator 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	90 aa 10.1 kDa	Yes	1
FXYD6-018 ENSP00000464144 ENST00000584230	E9PJ02 [Direct mapping] FXYD domain-containing ion transport regulator 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	90 aa 9.9 kDa	Yes	1
FXYD6-019 ENSP00000463158 ENST00000530956	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1
FXYD6-201 ENSP00000442756 ENST00000539526	Q9H0Q3 [Direct mapping] FXYD domain-containing ion transport regulator 6 A0A024R3J8 [Target identity:100%; Query identity:100%] FXYD domain containing ion transport regulator 6, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	95 aa 10.5 kDa	Yes	1

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