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FXYD2

GENERAL INFORMATION

Gene name

 FXYD2

Gene description

 FXYD domain containing ion transport regulator 2

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (kidney, gallbladder, salivary gland)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enhanced (kidney, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in distal renal tubules, bile duct cells, glandular cells in salivary gland, gallbladder and exocrine pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA068838
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, gallbladder, salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, salivary gland)

GENE INFORMATION

Gene name

 FXYD2 (HGNC Symbol)

Synonyms

 ATP1G1, HOMG2, MGC12372

Description

 FXYD domain containing ion transport regulator 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 117800844 - 117828698

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137731 (version 83.38)

Entrez gene

 486

UniProt

 P54710 (UniProt - Evidence at protein level)

neXtProt

 NX_P54710

Antibodypedia

 FXYD2 antibodies

PROTEIN BROWSER
FXYD2-001
FXYD2-002
FXYD2-004
FXYD2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FXYD2-001
ENSP00000260287
ENST00000260287
P54710 [Direct mapping]
Sodium/potassium-transporting ATPase subunit gamma
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005216 [ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990573 [potassium ion import across plasma membrane]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 64 aa
7.4 kDa 		No 1
FXYD2-002
ENSP00000292079
ENST00000292079
P54710 [Direct mapping]
Sodium/potassium-transporting ATPase subunit gamma
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005215 [transporter activity]
GO:0005216 [ion channel activity]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0042127 [regulation of cell proliferation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990573 [potassium ion import across plasma membrane]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 66 aa
7.3 kDa 		No 1
FXYD2-004
ENSP00000432430
ENST00000528014
P54710 [Direct mapping]
Sodium/potassium-transporting ATPase subunit gamma
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005216 [ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990573 [potassium ion import across plasma membrane]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 64 aa
7.4 kDa 		No 1
FXYD2-005
ENSP00000436414
ENST00000532119
P54710 [Direct mapping]
Sodium/potassium-transporting ATPase subunit gamma
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005216 [ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990573 [potassium ion import across plasma membrane]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 64 aa
7.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.