Tissue expression of SQRDL - Summary - The Human Protein Atlas

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SQRDL

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SQRDL
Gene description	Sulfide quinone reductase-like (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA017079 , HPA041589
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SQRDL (HGNC Symbol)
Synonyms	CGI-44
Description	Sulfide quinone reductase-like (yeast) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45631148 - 45691294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137767 (version 83.38)
Entrez gene	58472
UniProt	Q9Y6N5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6N5
Antibodypedia	SQRDL antibodies

PROTEIN BROWSER

SQRDL-001	SQRDL-002	SQRDL-003	SQRDL-004	SQRDL-005	SQRDL-006	SQRDL-007	SQRDL-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SQRDL-001 ENSP00000260324 ENST00000260324	Q9Y6N5 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial A0A024R5X2 [Target identity:100%; Query identity:100%] HCG2001986, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0005743 [mitochondrial inner membrane] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase] GO:0070224 [sulfide:quinone oxidoreductase activity] GO:0070813 [hydrogen sulfide metabolic process] Show all	450 aa 50 kDa	No	0
SQRDL-002 ENSP00000456019 ENST00000568606	Q9Y6N5 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial A0A024R5X2 [Target identity:100%; Query identity:100%] HCG2001986, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0005743 [mitochondrial inner membrane] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase] GO:0070224 [sulfide:quinone oxidoreductase activity] GO:0070813 [hydrogen sulfide metabolic process] Show all	450 aa 50 kDa	No	0
SQRDL-003 ENSP00000457592 ENST00000565227	H3BUD7 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.5 kDa	No	0
SQRDL-004 ENSP00000456979 ENST00000563296	H3BT21 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4 kDa	No	0
SQRDL-005 ENSP00000456075 ENST00000561735	H3BV36 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	141 aa 15.2 kDa	No	0
SQRDL-006 ENSP00000454953 ENST00000565997	H3BNP9 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14 kDa	No	0
SQRDL-007 ENSP00000454520 ENST00000566934	H3BMS6 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	181 aa 19.9 kDa	No	0
SQRDL-008 ENSP00000457937 ENST00000561493	H3BV36 [Direct mapping] Sulfide:quinone oxidoreductase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	141 aa 15.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.