Cell atlas - HAUS2 - The Human Protein Atlas

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HAUS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol
	Nucleoplasm

Human cell
	Centrosome
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HAUS2
Gene description	HAUS augmin-like complex, subunit 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039965
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the centrosome.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039965	A-431	Nucleoplasm
			Golgi apparatus
			Centrosome
			Cytosol
	HPA039965	U-2 OS	Nucleoplasm
	HPA039965	U-2 OS	Cytosol
	HPA039965	U-251 MG	Nucleoplasm
	HPA039965	U-251 MG	Cytosol

GENE INFORMATION
Gene name	HAUS2 (HGNC Symbol)
Synonyms	C15orf25, CEP27, FLJ10460, HsT17025
Description	HAUS augmin-like complex, subunit 2 (HGNC Symbol)
Entrez gene summary	HAUS2 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Chromosome	15
Cytoband	q15.2
Chromosome location (bp)	42548810 - 42569994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137814 (version 83.38)
Entrez gene	55142
UniProt	Q9NVX0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVX0
Antibodypedia	HAUS2 antibodies

PROTEIN BROWSER

HAUS2-001	HAUS2-002	HAUS2-005	HAUS2-007	HAUS2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAUS2-001 ENSP00000260372 ENST00000260372	Q9NVX0 [Direct mapping] HAUS augmin-like complex subunit 2 A0A024R9P0 [Target identity:100%; Query identity:100%] Centrosomal protein 27kDa, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0003674 [molecular_function] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0006996 [organelle organization] GO:0007067 [mitotic nuclear division] GO:0031023 [microtubule organizing center organization] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	235 aa 26.9 kDa	No	0
HAUS2-002 ENSP00000456578 ENST00000568876	Q9NVX0 [Direct mapping] HAUS augmin-like complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0003674 [molecular_function] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0007067 [mitotic nuclear division] GO:0031023 [microtubule organizing center organization] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	204 aa 23.3 kDa	No	0
HAUS2-005 ENSP00000455942 ENST00000562398	H3BQU2 [Direct mapping] HAUS augmin-like complex subunit 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031023 [microtubule organizing center organization] GO:0051225 [spindle assembly] Show all	180 aa 20.5 kDa	No	0
HAUS2-007 ENSP00000475743 ENST00000568846	J3QT48 [Direct mapping] HAUS augmin-like complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031023 [microtubule organizing center organization] GO:0051225 [spindle assembly] Show all	93 aa 10.1 kDa	No	0
HAUS2-011 ENSP00000475909 ENST00000607467	U3KQI5 [Direct mapping] HAUS augmin-like complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031023 [microtubule organizing center organization] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0070652 [HAUS complex] Show all	55 aa 6.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.