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TUBGCP4

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GENERAL INFORMATION

Gene name

 TUBGCP4

Gene description

 Tubulin, gamma complex associated protein 4

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Centrosome (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA043212
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the centrosome.

Main location

 Centrosome (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043212 A-431 Centrosome
HPA043212 U-2 OS No staining    
HPA043212 U-251 MG Centrosome

GENE INFORMATION

Gene name

 TUBGCP4 (HGNC Symbol)

Synonyms

 76P, FLJ14797

Description

 Tubulin, gamma complex associated protein 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43369221 - 43409771

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137822 (version 83.38)

Entrez gene

 27229

UniProt

 Q9UGJ1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGJ1

Antibodypedia

 TUBGCP4 antibodies

PROTEIN BROWSER
TUBGCP4-001
TUBGCP4-002
TUBGCP4-011
TUBGCP4-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBGCP4-001
ENSP00000260383
ENST00000260383
Q9UGJ1 [Direct mapping]
Gamma-tubulin complex component 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000923 [equatorial microtubule organizing center]
GO:0000930 [gamma-tubulin complex]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006461 [protein complex assembly]
GO:0007020 [microtubule nucleation]
GO:0007126 [meiotic nuclear division]
GO:0008274 [gamma-tubulin ring complex]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0031122 [cytoplasmic microtubule organization]
GO:0043015 [gamma-tubulin binding]
GO:0044732 [mitotic spindle pole body]
GO:0051011 [microtubule minus-end binding]
GO:0051298 [centrosome duplication]
GO:0051415 [interphase microtubule nucleation by interphase microtubule organizing center]
GO:0055037 [recycling endosome]
GO:0090307 [mitotic spindle assembly]
Show all
 667 aa
76.1 kDa 		No 0
TUBGCP4-002
ENSP00000456648
ENST00000564079
Q9UGJ1 [Direct mapping]
Gamma-tubulin complex component 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000923 [equatorial microtubule organizing center]
GO:0000930 [gamma-tubulin complex]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006461 [protein complex assembly]
GO:0007020 [microtubule nucleation]
GO:0007126 [meiotic nuclear division]
GO:0008274 [gamma-tubulin ring complex]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0031122 [cytoplasmic microtubule organization]
GO:0043015 [gamma-tubulin binding]
GO:0044732 [mitotic spindle pole body]
GO:0051011 [microtubule minus-end binding]
GO:0051298 [centrosome duplication]
GO:0051415 [interphase microtubule nucleation by interphase microtubule organizing center]
GO:0055037 [recycling endosome]
GO:0090307 [mitotic spindle assembly]
Show all
 666 aa
76 kDa 		No 0
TUBGCP4-011
ENSP00000454915
ENST00000563147
H3BNL9 [Direct mapping]
Gamma-tubulin complex component 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000922 [spindle pole]
GO:0005815 [microtubule organizing center]
Show all
 171 aa
20.1 kDa 		No 0
TUBGCP4-012
ENSP00000456550
ENST00000565548
H3BS59 [Direct mapping]
Gamma-tubulin complex component 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000922 [spindle pole]
GO:0005815 [microtubule organizing center]
Show all
 105 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.