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PLCB2

CANCER ATLAS

Gene description

 Phospholipase C, beta 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009443

GENE INFORMATION

Gene name

 PLCB2 (HGNC Symbol)

Synonyms

 FLJ38135

Description

 Phospholipase C, beta 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40278176 - 40307935

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137841 (version 83.38)

Entrez gene

 5330

UniProt

 Q00722 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00722

Antibodypedia

 PLCB2 antibodies

PROTEIN BROWSER
PLCB2-001
PLCB2-002
PLCB2-003
PLCB2-004
PLCB2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCB2-001
ENSP00000260402
ENST00000260402
Q00722 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050913 [sensory perception of bitter taste]
Show all
 1185 aa
134 kDa 		No 0
PLCB2-002
ENSP00000444652
ENST00000543785
Q9BVT6 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLCB2 protein; Phospholipase C, beta 2; Phospholipase C, beta 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004629 [phospholipase C activity]
GO:0005622 [intracellular]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 199 aa
22.7 kDa 		No 0
PLCB2-003
ENSP00000411991
ENST00000456256
Q00722 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1170 aa
132.5 kDa 		No 0
PLCB2-004
ENSP00000453975
ENST00000557821
Q00722 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1181 aa
133.7 kDa 		No 0
PLCB2-013
ENSP00000452916
ENST00000559671
H0YKR9 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 87 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.