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DUOX1

GENERAL INFORMATION

Gene name

 DUOX1

Gene description

 Dual oxidase 1

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin, thyroid gland)
GTEx:Tissue enhanced (thyroid gland, esophagus, lung)
FANTOM5:Tissue enhanced (lung, epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in epithelial cells, most abundant in gastrointestinal tract thyroid gland and respiratory tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in a subset of structures are not annotated as epithelial cells, view images.

Reliability score

 Approved based on 1 antibody.
HPA023544
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland, esophagus, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, epididymis)

GENE INFORMATION

Gene name

 DUOX1 (HGNC Symbol)

Synonyms

 LNOX1, NOXEF1, THOX1

Description

 Dual oxidase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 45129933 - 45165576

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137857 (version 83.38)

Entrez gene

 53905

UniProt

 Q9NRD9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRD9

Antibodypedia

 DUOX1 antibodies

PROTEIN BROWSER
DUOX1-001
DUOX1-005
DUOX1-006
DUOX1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUOX1-001
ENSP00000373689
ENST00000389037
Q9NRD9 [Direct mapping]
Dual oxidase 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0006590 [thyroid hormone generation]
GO:0006979 [response to oxidative stress]
GO:0016021 [integral component of membrane]
GO:0016174 [NAD(P)H oxidase activity]
GO:0016324 [apical plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0020037 [heme binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042335 [cuticle development]
GO:0042446 [hormone biosynthetic process]
GO:0042554 [superoxide anion generation]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
Show all
 1551 aa
177.2 kDa 		Yes 7
DUOX1-005
ENSP00000454065
ENST00000561166
Q9NRD9 [Direct mapping]
Dual oxidase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0006590 [thyroid hormone generation]
GO:0006979 [response to oxidative stress]
GO:0016021 [integral component of membrane]
GO:0016174 [NAD(P)H oxidase activity]
GO:0016324 [apical plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0020037 [heme binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042335 [cuticle development]
GO:0042446 [hormone biosynthetic process]
GO:0042554 [superoxide anion generation]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
Show all
 1197 aa
137.6 kDa 		Yes 7
DUOX1-006
ENSP00000317997
ENST00000321429
Q9NRD9 [Direct mapping]
Dual oxidase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006590 [thyroid hormone generation]
GO:0006979 [response to oxidative stress]
GO:0016021 [integral component of membrane]
GO:0016174 [NAD(P)H oxidase activity]
GO:0016324 [apical plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0020037 [heme binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042335 [cuticle development]
GO:0042446 [hormone biosynthetic process]
GO:0042554 [superoxide anion generation]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
GO:0072593 [reactive oxygen species metabolic process]
Show all
 1551 aa
177.2 kDa 		Yes 7
DUOX1-007
ENSP00000454121
ENST00000558322
H0YNR5 [Direct mapping]
Dual oxidase 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 43 aa
5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.