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A few cases of colorectal, breast, endometrial, ovarian, cervical and lung cancers showed moderate cytoplasmic and/or membranous immunoreactivity. Remaining cancer cells were generally negative.
GENE INFORMATION
Gene name
STRA6 (HGNC Symbol)
Synonyms
FLJ12541
Description
Stimulated by retinoic acid 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]