Expression of BCL2L10 in cancer - Summary

CANCER ATLAS

Gene description

BCL2-like 10 (apoptosis facilitator)

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042222

GENE INFORMATION
Gene name	BCL2L10 (HGNC Symbol)
Synonyms	BCL-B, Boo, Diva
Description	BCL2-like 10 (apoptosis facilitator) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	52109263 - 52112775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137875 (version 83.38)
Entrez gene	10017
UniProt	Q9HD36 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD36
Antibodypedia	BCL2L10 antibodies

PROTEIN BROWSER

BCL2L10-001	BCL2L10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2L10-001 ENSP00000260442 ENST00000260442	Q9HD36 [Direct mapping] Bcl-2-like protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007283 [spermatogenesis] GO:0007292 [female gamete generation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	204 aa 23.2 kDa	No	1
BCL2L10-002 ENSP00000453562 ENST00000561198	H0YMD5 [Direct mapping] Bcl-2-like protein 10 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	241 aa 26.7 kDa	No	0