Cell atlas - GTF2B - The Human Protein Atlas

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GTF2B

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GTF2B
Gene description	General transcription factor IIB
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nuclear bodies (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061626
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nuclear bodies.

Main location

Nucleus (supported), Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061626	HEK 293	Nucleus	Intensity
	HPA061626	HEK 293	Nuclear bodies
	HPA061626	RH-30	Nucleus
	HPA061626	RH-30	Nuclear bodies
	HPA061626	U-2 OS	Nucleus
	HPA061626	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	GTF2B (HGNC Symbol)
Synonyms	TFIIB
Description	General transcription factor IIB (HGNC Symbol)
Entrez gene summary	This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p22.2
Chromosome location (bp)	88852932 - 88891944
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137947 (version 83.38)
Entrez gene	2959
UniProt	Q00403 (UniProt - Evidence at protein level)
neXtProt	NX_Q00403
Antibodypedia	GTF2B antibodies

PROTEIN BROWSER

GTF2B-001	GTF2B-002	GTF2B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTF2B-001 ENSP00000359531 ENST00000370500	Q00403 [Direct mapping] Transcription initiation factor IIB Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0017025 [TBP-class protein binding] GO:0046966 [thyroid hormone receptor binding] Show all	316 aa 34.8 kDa	No	0
GTF2B-002 ENSP00000402345 ENST00000418217	B1APE2 [Direct mapping] Transcription initiation factor IIB Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0017025 [TBP-class protein binding] Show all	231 aa 25.6 kDa	No	0
GTF2B-003 ENSP00000415741 ENST00000448623	B1APE1 [Direct mapping] Transcription initiation factor IIB Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0017025 [TBP-class protein binding] Show all	224 aa 25 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.