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Cancer cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Several cervical squamous cell carcinomas, prostate and renal cancers cancers were weakly stained or negative.
A majority of cancer cells displayed moderate granular cytoplasmic staining. A few cases of melanomas, testicular, gastric, pancreatic and colorectal cancers displayed strong positivity.
Most cancer showed moderate cytoplasmic immunoreactivity. Nuclear positivity was observed in several cases. A few cases of colorectal cancers were strongly stained. Several lymphomas and gliomas were weakly stained.
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)