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LHCGR

CANCER ATLAS

Gene description

 Luteinizing hormone/choriogonadotropin receptor

Protein class

 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009814

GENE INFORMATION

Gene name

 LHCGR (HGNC Symbol)

Synonyms

 HHG, LCGR, LGR2, LHR, ULG5

Description

 Luteinizing hormone/choriogonadotropin receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p16.3

Chromosome location (bp)

 48686775 - 48755730

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138039 (version 83.38)

Entrez gene

 3973

UniProt

 P22888 (UniProt - Evidence at protein level)

neXtProt

 NX_P22888

Antibodypedia

 LHCGR antibodies

PROTEIN BROWSER
LHCGR-001
LHCGR-003
LHCGR-004
LHCGR-006
LHCGR-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LHCGR-001
ENSP00000294954
ENST00000294954
P22888 [Direct mapping]
Lutropin-choriogonadotropic hormone receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004964 [luteinizing hormone receptor activity]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008584 [male gonad development]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0022602 [ovulation cycle process]
GO:0030539 [male genitalia development]
GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process]
GO:0035472 [choriogonadotropin hormone receptor activity]
GO:0038106 [choriogonadotropin hormone binding]
GO:0042700 [luteinizing hormone signaling pathway]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0050890 [cognition]
GO:0060065 [uterus development]
GO:0071371 [cellular response to gonadotropin stimulus]
Show all
 699 aa
78.6 kDa 		Yes 7
LHCGR-003
ENSP00000386033
ENST00000405626
E7ENI1 [Direct mapping]
Lutropin-choriogonadotropic hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004964 [luteinizing hormone receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0022602 [ovulation cycle process]
GO:0042700 [luteinizing hormone signaling pathway]
GO:0060065 [uterus development]
Show all
 672 aa
75.5 kDa 		Yes 7
LHCGR-004
ENSP00000385847
ENST00000403273
E7ESK4 [Direct mapping]
Lutropin-choriogonadotropic hormone receptor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004964 [luteinizing hormone receptor activity]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0022602 [ovulation cycle process]
GO:0042700 [luteinizing hormone signaling pathway]
GO:0060065 [uterus development]
Show all
 329 aa
36.5 kDa 		Yes 0
LHCGR-006
ENSP00000385406
ENST00000401907
E7EQB5 [Direct mapping]
Lutropin-choriogonadotropic hormone receptor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004964 [luteinizing hormone receptor activity]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0022602 [ovulation cycle process]
GO:0042700 [luteinizing hormone signaling pathway]
GO:0060065 [uterus development]
Show all
 325 aa
36.3 kDa 		Yes 0
LHCGR-007
ENSP00000403748
ENST00000428232
H7C226 [Direct mapping]
Lutropin-choriogonadotropic hormone receptor
Show all
Predicted intracellular proteins
Show all
GO:0004964 [luteinizing hormone receptor activity]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0022602 [ovulation cycle process]
GO:0042700 [luteinizing hormone signaling pathway]
GO:0060065 [uterus development]
Show all
 175 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.