Tissue expression of PREPL - Summary - The Human Protein Atlas

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PREPL

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PREPL
Gene description	Prolyl endopeptidase-like
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA063238
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PREPL (HGNC Symbol)
Synonyms	KIAA0436
Description	Prolyl endopeptidase-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	44316281 - 44361862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138078 (version 83.38)
Entrez gene	9581
UniProt	Q4J6C6 (UniProt - Evidence at protein level)
neXtProt	NX_Q4J6C6
Antibodypedia	PREPL antibodies

PROTEIN BROWSER

PREPL-001	PREPL-002	PREPL-003	PREPL-004	PREPL-005	PREPL-006	PREPL-007	PREPL-008	PREPL-013	PREPL-014	PREPL-015	PREPL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PREPL-001 ENSP00000367772 ENST00000378511	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	665 aa 76.8 kDa	No	0
PREPL-002 ENSP00000367781 ENST00000378520	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	661 aa 76.4 kDa	No	0
PREPL-003 ENSP00000260648 ENST00000260648	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	727 aa 83.9 kDa	No	0
PREPL-004 ENSP00000386509 ENST00000410081	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	727 aa 83.9 kDa	No	0
PREPL-005 ENSP00000386909 ENST00000409272	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	727 aa 83.9 kDa	No	0
PREPL-006 ENSP00000387241 ENST00000409957	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	638 aa 73.4 kDa	No	0
PREPL-007 ENSP00000387095 ENST00000409411	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	638 aa 73.4 kDa	No	0
PREPL-008 ENSP00000386543 ENST00000409936	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	727 aa 83.9 kDa	No	0
PREPL-013 ENSP00000395034 ENST00000438314	C9JMT4 [Direct mapping] Prolyl endopeptidase-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	151 aa 17.9 kDa	No	0
PREPL-014 ENSP00000390618 ENST00000444696	H7BZP6 [Direct mapping] Prolyl endopeptidase-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	70 aa 8.1 kDa	No	0
PREPL-015 ENSP00000395692 ENST00000420756	H7C0M0 [Direct mapping] Prolyl endopeptidase-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	120 aa 13.5 kDa	No	0
PREPL-201 ENSP00000439626 ENST00000541738	Q4J6C6 [Direct mapping] Prolyl endopeptidase-like Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070008 [serine-type exopeptidase activity] Show all	638 aa 73.4 kDa	No	0

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