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SLC3A1

GENERAL INFORMATION

Gene name

 SLC3A1

Gene description

 Solute carrier family 3 (amino acid transporter heavy chain), member 1

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Group enriched (kidney, small intestine, pancreas)
FANTOM5:Tissue enhanced (kidney, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues, most abundant in small intestines and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA038360
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, small intestine, pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, small intestine)

GENE INFORMATION

Gene name

 SLC3A1 (HGNC Symbol)

Synonyms

 ATR1, CSNU1, D2H, NBAT, RBAT

Description

 Solute carrier family 3 (amino acid transporter heavy chain), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 44275458 - 44321494

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138079 (version 83.38)

Entrez gene

 6519

UniProt

 Q07837 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07837

Antibodypedia

 SLC3A1 antibodies

PROTEIN BROWSER
SLC3A1-001
SLC3A1-002
SLC3A1-003
SLC3A1-004
SLC3A1-005
SLC3A1-006
SLC3A1-007
SLC3A1-008
SLC3A1-009
SLC3A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC3A1-001
ENSP00000260649
ENST00000260649
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005774 [vacuolar membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 685 aa
78.9 kDa 		No 1
SLC3A1-002
ENSP00000387308
ENST00000409387
B8ZZK1 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016021 [integral component of membrane]
GO:0043169 [cation binding]
Show all
 564 aa
65 kDa 		No 1
SLC3A1-003
ENSP00000387337
ENST00000410056
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 391 aa
45.4 kDa 		No 1
SLC3A1-004
ENSP00000386954
ENST00000409741
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 502 aa
58 kDa 		No 1
SLC3A1-005
ENSP00000386620
ENST00000409229
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 564 aa
65 kDa 		No 1
SLC3A1-006
ENSP00000386709
ENST00000409380
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 407 aa
46.7 kDa 		No 0
SLC3A1-007
ENSP00000386677
ENST00000409740
Q07837 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015802 [basic amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0043169 [cation binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 316 aa
35.9 kDa 		No 0
SLC3A1-008
ENSP00000391642
ENST00000427285
C9JBK3 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005975 [carbohydrate metabolic process]
GO:0043169 [cation binding]
Show all
 143 aa
16.8 kDa 		Yes 0
SLC3A1-009
ENSP00000386852
ENST00000409294
B8ZZP2 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005975 [carbohydrate metabolic process]
GO:0043169 [cation binding]
Show all
 184 aa
20.7 kDa 		No 0
SLC3A1-201
ENSP00000483618
ENST00000611973
A0A087X0R9 [Direct mapping]
Neutral and basic amino acid transport protein rBAT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016021 [integral component of membrane]
GO:0043169 [cation binding]
Show all
 552 aa
63.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.