Cell atlas - FBXO11 - The Human Protein Atlas

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FBXO11

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FBXO11
Gene description	F-box protein 11
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA002690
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002690	A-431	Nucleus
	HPA002690	A-431	Nucleoli
	HPA002690	U-2 OS	Nucleus
	HPA002690	U-251 MG	Nucleus
			Nucleoli
			Cytosol

GENE INFORMATION
Gene name	FBXO11 (HGNC Symbol)
Synonyms	FBX11, UBR6
Description	F-box protein 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Chromosome	2
Cytoband	p16.3
Chromosome location (bp)	47789316 - 47905793
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138081 (version 83.38)
Entrez gene	80204
UniProt	Q86XK2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XK2
Antibodypedia	FBXO11 antibodies

PROTEIN BROWSER

FBXO11-001	FBXO11-004	FBXO11-006	FBXO11-008	FBXO11-014	FBXO11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO11-001 ENSP00000384823 ENST00000403359	Q86XK2 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007605 [sensory perception of sound] GO:0008270 [zinc ion binding] GO:0016274 [protein-arginine N-methyltransferase activity] GO:0016567 [protein ubiquitination] GO:0035246 [peptidyl-arginine N-methylation] Show all	927 aa 103.6 kDa	No	0
FBXO11-004 ENSP00000392272 ENST00000424163	C9IYF0 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	140 aa 16 kDa	No	0
FBXO11-006 ENSP00000428118 ENST00000493962	H0YAV3 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		562 aa 62.4 kDa	No	0
FBXO11-008 ENSP00000385398 ENST00000402508	Q86XK2 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008270 [zinc ion binding] GO:0016274 [protein-arginine N-methyltransferase activity] GO:0016567 [protein ubiquitination] GO:0035246 [peptidyl-arginine N-methylation] Show all	843 aa 94.1 kDa	No	0
FBXO11-014 ENSP00000385127 ENST00000405808	B5MCV6 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	57 aa 6.5 kDa	No	0
FBXO11-201 ENSP00000323822 ENST00000316377	A0A0A0MR53 [Direct mapping] F-box only protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	591 aa 67 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.