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SIX3

GENERAL INFORMATION

Gene name

 SIX3

Gene description

 SIX homeobox 3

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Group enriched (pituitary gland, caudate, hypothalamus)
FANTOM5:Group enriched (retina, pituitary gland, caudate)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (retina, pituitary gland, caudate)

GENE INFORMATION

Gene name

 SIX3 (HGNC Symbol)

Synonyms

 HPE2

Description

 SIX homeobox 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 44941898 - 44946077

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138083 (version 83.38)

Entrez gene

 6496

UniProt

 O95343 (UniProt - Evidence at protein level)

neXtProt

 NX_O95343

Antibodypedia

 SIX3 antibodies

PROTEIN BROWSER
SIX3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIX3-001
ENSP00000260653
ENST00000260653
O95343 [Direct mapping]
Homeobox protein SIX3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001222 [transcription corepressor binding]
GO:0001654 [eye development]
GO:0002070 [epithelial cell maturation]
GO:0002088 [lens development in camera-type eye]
GO:0003404 [optic vesicle morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0009946 [proximal/distal axis specification]
GO:0014016 [neuroblast differentiation]
GO:0021536 [diencephalon development]
GO:0021537 [telencephalon development]
GO:0021797 [forebrain anterior/posterior pattern specification]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021846 [cell proliferation in forebrain]
GO:0021978 [telencephalon regionalization]
GO:0021983 [pituitary gland development]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048512 [circadian behavior]
GO:0060235 [lens induction in camera-type eye]
GO:0061074 [regulation of neural retina development]
GO:0070306 [lens fiber cell differentiation]
GO:0097402 [neuroblast migration]
GO:1901987 [regulation of cell cycle phase transition]
GO:1902692 [regulation of neuroblast proliferation]
GO:1902742 [apoptotic process involved in development]
GO:1990086 [lens fiber cell apoptotic process]
GO:2000177 [regulation of neural precursor cell proliferation]
Show all
 332 aa
35.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.