Fields »
ABOUT
HELP
BLOG
LRPPRC

GENERAL INFORMATION

Gene name

 LRPPRC

Gene description

 Leucine-rich pentatricopeptide repeat containing

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA036408 , HPA036409 , CAB033786
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LRPPRC (HGNC Symbol)

Synonyms

 GP130, LRP130, LSFC

Description

 Leucine-rich pentatricopeptide repeat containing (HGNC Symbol)

Entrez gene summary

 This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 43886508 - 43996005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138095 (version 83.38)

Entrez gene

 10128

UniProt

 P42704 (UniProt - Evidence at protein level)

neXtProt

 NX_P42704

Antibodypedia

 LRPPRC antibodies

PROTEIN BROWSER
LRPPRC-001
LRPPRC-002
LRPPRC-003
LRPPRC-005
LRPPRC-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRPPRC-001
ENSP00000260665
ENST00000260665
P42704 [Direct mapping]
Leucine-rich PPR motif-containing protein, mitochondrial
E5KNY5 [Target identity:100%; Query identity:100%]
Leucine-rich PPR-motif containing; Mitochondrial leucine-rich PPR motif-containing protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0000961 [negative regulation of mitochondrial RNA catabolic process]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008017 [microtubule binding]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
GO:0047497 [mitochondrion transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051028 [mRNA transport]
GO:0070129 [regulation of mitochondrial translation]
Show all
 1394 aa
157.9 kDa 		No 0
LRPPRC-002
ENSP00000386234
ENST00000409946
A0A0C4DG06 [Direct mapping]
Leucine-rich PPR motif-containing protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 531 aa
59.3 kDa 		No 0
LRPPRC-003
ENSP00000403637
ENST00000447246
C9JCA9 [Direct mapping]
Leucine-rich PPR motif-containing protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
Show all
 359 aa
40.1 kDa 		No 0
LRPPRC-005
ENSP00000386562
ENST00000409659
B8ZZ38 [Direct mapping]
Leucine-rich PPR motif-containing protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
Show all
 504 aa
56.3 kDa 		No 0
LRPPRC-009
ENSP00000414207
ENST00000419884
H7C3W8 [Direct mapping]
Leucine-rich PPR motif-containing protein, mitochondrial
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 77 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.