Fields »
ABOUT
HELP
BLOG
TRIM54

GENERAL INFORMATION

Gene name

 TRIM54

Gene description

 Tripartite motif containing 54

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle, heart muscle)
GTEx:Group enriched (skeletal muscle, heart muscle)
FANTOM5:Group enriched (skeletal muscle, heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA019690
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)

GENE INFORMATION

Gene name

 TRIM54 (HGNC Symbol)

Synonyms

 MURF, MURF-3, RNF30

Description

 Tripartite motif containing 54 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27282392 - 27307439

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138100 (version 83.38)

Entrez gene

 57159

UniProt

 Q9BYV2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYV2

Antibodypedia

 TRIM54 antibodies

PROTEIN BROWSER
TRIM54-001
TRIM54-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM54-001
ENSP00000296098
ENST00000296098
Q9BYV2 [Direct mapping]
Tripartite motif-containing protein 54
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0030018 [Z disc]
GO:0030154 [cell differentiation]
Show all
 400 aa
44.8 kDa 		No 0
TRIM54-002
ENSP00000369415
ENST00000380075
Q9BYV2 [Direct mapping]
Tripartite motif-containing protein 54
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0030018 [Z disc]
GO:0030154 [cell differentiation]
Show all
 358 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.