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DTNB

GENERAL INFORMATION

Gene name

 DTNB

Gene description

 Dystrobrevin, beta

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA061357
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DTNB

Synonyms

Description

 Dystrobrevin, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 25377198 - 25673647

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138101 (version 83.38)

Entrez gene

 1838

UniProt

 O60941 (UniProt - Evidence at protein level)

neXtProt

 NX_O60941

Antibodypedia

 DTNB antibodies

PROTEIN BROWSER
DTNB-001
DTNB-003
DTNB-004
DTNB-005
DTNB-006
DTNB-010
DTNB-022
DTNB-024
DTNB-201
DTNB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DTNB-001
ENSP00000384084
ENST00000406818
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0045202 [synapse]
Show all
 627 aa
71.4 kDa 		No 0
DTNB-003
ENSP00000385482
ENST00000404103
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 597 aa
68.1 kDa 		No 0
DTNB-004
ENSP00000385193
ENST00000407661
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 609 aa
69.3 kDa 		No 0
DTNB-005
ENSP00000384767
ENST00000407038
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 567 aa
64.6 kDa 		No 0
DTNB-006
ENSP00000384787
ENST00000405222
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 560 aa
63.8 kDa 		No 0
DTNB-010
ENSP00000385784
ENST00000407186
E9PEY4 [Direct mapping]
Dystrobrevin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 590 aa
67.1 kDa 		No 0
DTNB-022
ENSP00000306529
ENST00000303659
F8W9U0 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 188 aa
21.6 kDa 		No 0
DTNB-024
ENSP00000340957
ENST00000349996
E9PE76 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 132 aa
15.4 kDa 		No 0
DTNB-201
ENSP00000288642
ENST00000288642
E7EVB6 [Direct mapping]
Dystrobrevin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 620 aa
70.5 kDa 		No 0
DTNB-202
ENSP00000444463
ENST00000496972
O60941 [Direct mapping]
Dystrobrevin beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 545 aa
61.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.