Tissue expression of DTNB - Summary - The Human Protein Atlas

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DTNB

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DTNB
Gene description	Dystrobrevin, beta
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA061357
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DTNB
Synonyms
Description	Dystrobrevin, beta (HGNC Symbol)
Entrez gene summary	This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	25377198 - 25673647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138101 (version 83.38)
Entrez gene	1838
UniProt	O60941 (UniProt - Evidence at protein level)
neXtProt	NX_O60941
Antibodypedia	DTNB antibodies

PROTEIN BROWSER

DTNB-001	DTNB-003	DTNB-004	DTNB-005	DTNB-006	DTNB-010	DTNB-022	DTNB-024	DTNB-201	DTNB-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DTNB-001 ENSP00000384084 ENST00000406818	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0045202 [synapse] Show all	627 aa 71.4 kDa	No	0
DTNB-003 ENSP00000385482 ENST00000404103	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	597 aa 68.1 kDa	No	0
DTNB-004 ENSP00000385193 ENST00000407661	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	609 aa 69.3 kDa	No	0
DTNB-005 ENSP00000384767 ENST00000407038	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	567 aa 64.6 kDa	No	0
DTNB-006 ENSP00000384787 ENST00000405222	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	560 aa 63.8 kDa	No	0
DTNB-010 ENSP00000385784 ENST00000407186	E9PEY4 [Direct mapping] Dystrobrevin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	590 aa 67.1 kDa	No	0
DTNB-022 ENSP00000306529 ENST00000303659	F8W9U0 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 21.6 kDa	No	0
DTNB-024 ENSP00000340957 ENST00000349996	E9PE76 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.4 kDa	No	0
DTNB-201 ENSP00000288642 ENST00000288642	E7EVB6 [Direct mapping] Dystrobrevin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	620 aa 70.5 kDa	No	0
DTNB-202 ENSP00000444463 ENST00000496972	O60941 [Direct mapping] Dystrobrevin beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	545 aa 61.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.