Cell atlas - CH25H - The Human Protein Atlas

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CH25H

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CH25H
Gene description	Cholesterol 25-hydroxylase
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (U-138 MG, U-87 MG, ASC TERT1, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG, U-87 MG, ASC TERT1, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CH25H
Synonyms
Description	Cholesterol 25-hydroxylase (HGNC Symbol)
Entrez gene summary	This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	89205629 - 89207314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138135 (version 83.38)
Entrez gene	9023
UniProt	O95992 (UniProt - Evidence at protein level)
neXtProt	NX_O95992
Antibodypedia	CH25H antibodies

PROTEIN BROWSER

CH25H-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CH25H-001 ENSP00000360918 ENST00000371852	O95992 [Direct mapping] Cholesterol 25-hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0001567 [cholesterol 25-hydroxylase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006699 [bile acid biosynthetic process] GO:0008203 [cholesterol metabolic process] GO:0008206 [bile acid metabolic process] GO:0008395 [steroid hydroxylase activity] GO:0016021 [integral component of membrane] GO:0016126 [sterol biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	272 aa 31.7 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.