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KIF20B

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GENERAL INFORMATION

Gene name

 KIF20B

Gene description

 Kinesin family member 20B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the midbody & nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Midbody (supported)

Additional location

 In addition localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition and custom assay

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA050214
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ASSAYS
RNA expression
Human cells
Custom data
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the midbody & nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated), Midbody (supported)

Additional location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050214 A-431 Nucleoplasm Intensity
HPA050214 U-2 OS Nucleoplasm Intensity Intensity
Midbody Intensity Intensity
Cytosol
HPA050214 U-251 MG Nucleoplasm

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA050214 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. KIF20B is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition and custom assay

Intensity variation

 Nucleoplasm

GFP

Antibody

 HPA050214

Validation

N-terminal tag
BAC cell line: 5120
Validated: Antibody staining overlaps with GFP tagged protein but show additional locations

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA050214 HeLa 5120 N-terminal Nucleoplasm, Cytosol Nucleoplasm
HPA050214 HeLa Normal - Nucleoplasm, Cytosol -

GENE INFORMATION

Gene name

 KIF20B (HGNC Symbol)

Synonyms

 CT90, KRMP1, MPHOSPH1, MPP1

Description

 Kinesin family member 20B (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q23.31

Chromosome location (bp)

 89701610 - 89774939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138182 (version 83.38)

Entrez gene

 9585

UniProt

 Q96Q89 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96Q89

Antibodypedia

 KIF20B antibodies

PROTEIN BROWSER
KIF20B-001
KIF20B-003
KIF20B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF20B-001
ENSP00000260753
ENST00000260753
Q96Q89 [Direct mapping]
Kinesin-like protein KIF20B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007050 [cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016887 [ATPase activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0035372 [protein localization to microtubule]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0050699 [WW domain binding]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0070938 [contractile ring]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097431 [mitotic spindle pole]
GO:1903438 [positive regulation of mitotic cytokinetic process]
GO:1990023 [mitotic spindle midzone]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
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 1780 aa
206.1 kDa 		No 0
KIF20B-003
ENSP00000360793
ENST00000371728
Q96Q89 [Direct mapping]
Kinesin-like protein KIF20B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007050 [cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0015630 [microtubule cytoskeleton]
GO:0016887 [ATPase activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0032467 [positive regulation of cytokinesis]
GO:0035372 [protein localization to microtubule]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0050699 [WW domain binding]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0070201 [regulation of establishment of protein localization]
GO:0070938 [contractile ring]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097431 [mitotic spindle pole]
GO:1903438 [positive regulation of mitotic cytokinetic process]
GO:1990023 [mitotic spindle midzone]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001222 [regulation of neuron migration]
GO:2001224 [positive regulation of neuron migration]
Show all
 1820 aa
210.6 kDa 		No 0
KIF20B-004
ENSP00000390946
ENST00000447580
A0A0A0MSJ5 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
Show all
 206 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.