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PLCE1

CANCER ATLAS

Gene description

 Phospholipase C, epsilon 1

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015597
HPA015598

GENE INFORMATION

Gene name

 PLCE1 (HGNC Symbol)

Synonyms

 KIAA1516, NPHS3, PLCE

Description

 Phospholipase C, epsilon 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q23.33

Chromosome location (bp)

 93993989 - 94332823

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138193 (version 83.38)

Entrez gene

 51196

UniProt

 Q9P212 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P212

Antibodypedia

 PLCE1 antibodies

PROTEIN BROWSER
PLCE1-001
PLCE1-002
PLCE1-201
PLCE1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCE1-001
ENSP00000360431
ENST00000371380
Q9P212 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000187 [activation of MAPK activity]
GO:0001558 [regulation of cell growth]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007507 [heart development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0016042 [lipid catabolic process]
GO:0017016 [Ras GTPase binding]
GO:0019722 [calcium-mediated signaling]
GO:0019899 [enzyme binding]
GO:0032835 [glomerulus development]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 2302 aa
258.7 kDa 		No 0
PLCE1-002
ENSP00000360426
ENST00000371375
Q9P212 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000187 [activation of MAPK activity]
GO:0001558 [regulation of cell growth]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007507 [heart development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0016042 [lipid catabolic process]
GO:0017016 [Ras GTPase binding]
GO:0019722 [calcium-mediated signaling]
GO:0019899 [enzyme binding]
GO:0032835 [glomerulus development]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 1994 aa
223.9 kDa 		No 0
PLCE1-201
ENSP00000260766
ENST00000260766
Q9P212 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000187 [activation of MAPK activity]
GO:0001558 [regulation of cell growth]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007507 [heart development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0016042 [lipid catabolic process]
GO:0017016 [Ras GTPase binding]
GO:0019722 [calcium-mediated signaling]
GO:0019899 [enzyme binding]
GO:0032835 [glomerulus development]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 2302 aa
258.7 kDa 		No 0
PLCE1-202
ENSP00000360438
ENST00000371385
Q9P212 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000187 [activation of MAPK activity]
GO:0001558 [regulation of cell growth]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007507 [heart development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0016042 [lipid catabolic process]
GO:0017016 [Ras GTPase binding]
GO:0019722 [calcium-mediated signaling]
GO:0019899 [enzyme binding]
GO:0032835 [glomerulus development]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 1994 aa
223.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.