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DNA2

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GENERAL INFORMATION

Gene name

 DNA2

Gene description

 DNA replication helicase/nuclease 2

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA057526
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057526 A-431 Nucleus
Mitochondria Intensity
HPA057526 CACO-2 Mitochondria Intensity
HPA057526 U-2 OS Mitochondria Intensity

GENE INFORMATION

Gene name

 DNA2 (HGNC Symbol)

Synonyms

 DNA2L, KIAA0083

Description

 DNA replication helicase/nuclease 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 68414064 - 68472121

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138346 (version 83.38)

Entrez gene

 1763

UniProt

 P51530 (UniProt - Evidence at protein level)

neXtProt

 NX_P51530

Antibodypedia

 DNA2 antibodies

PROTEIN BROWSER
DNA2-001
DNA2-002
DNA2-005
DNA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNA2-001
ENSP00000351185
ENST00000358410
P51530 [Direct mapping]
DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000729 [DNA double-strand break processing]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0004386 [helicase activity]
GO:0004518 [nuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005760 [gamma DNA polymerase complex]
GO:0006260 [DNA replication]
GO:0006264 [mitochondrial DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base]
GO:0017108 [5'-flap endonuclease activity]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0032508 [DNA duplex unwinding]
GO:0033567 [DNA replication, Okazaki fragment processing]
GO:0042645 [mitochondrial nucleoid]
GO:0043137 [DNA replication, removal of RNA primer]
GO:0043139 [5'-3' DNA helicase activity]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0043504 [mitochondrial DNA repair]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045740 [positive regulation of DNA replication]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 1060 aa
120.4 kDa 		No 0
DNA2-002
ENSP00000389713
ENST00000440722
H0Y455 [Direct mapping]
DNA replication ATP-dependent helicase/nuclease DNA2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0017108 [5'-flap endonuclease activity]
GO:0033567 [DNA replication, Okazaki fragment processing]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
Show all
 375 aa
42.2 kDa 		No 0
DNA2-005
ENSP00000450393
ENST00000551118
F8VR31 [Direct mapping]
DNA replication ATP-dependent helicase/nuclease DNA2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0017108 [5'-flap endonuclease activity]
GO:0033567 [DNA replication, Okazaki fragment processing]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
Show all
 867 aa
98.6 kDa 		No 0
DNA2-201
ENSP00000382133
ENST00000399180
P51530 [Direct mapping]
DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000076 [DNA replication checkpoint]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000729 [DNA double-strand break processing]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0004386 [helicase activity]
GO:0004518 [nuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005760 [gamma DNA polymerase complex]
GO:0006260 [DNA replication]
GO:0006264 [mitochondrial DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base]
GO:0017108 [5'-flap endonuclease activity]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0032508 [DNA duplex unwinding]
GO:0033567 [DNA replication, Okazaki fragment processing]
GO:0042645 [mitochondrial nucleoid]
GO:0043137 [DNA replication, removal of RNA primer]
GO:0043139 [5'-3' DNA helicase activity]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0043504 [mitochondrial DNA repair]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045740 [positive regulation of DNA replication]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 687 aa
78.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.