We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer tissues showed moderate staining in most cases. Strong immunoreactivity was observed in most colorectal, testicular, melanomas, breast, stomach and pancreatic cancers. Renal cancers were in most cases weakly stained or negative.
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
P31939 [Direct mapping] Bifunctional purine biosynthesis protein PURH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase Bifunctional purine biosynthesis protein PURH, N-terminally processed V9HWH7 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 70p
Show all
Enzymes ENZYME proteins Transferases Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P31939 [Direct mapping] Bifunctional purine biosynthesis protein PURH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase Bifunctional purine biosynthesis protein PURH, N-terminally processed
Show all
Enzymes ENZYME proteins Transferases Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
C9JLK0 [Direct mapping] Bifunctional purine biosynthesis protein PURH
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)