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This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Q99728 [Direct mapping] BRCA1-associated RING domain protein 1
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Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0001894 [tissue homeostasis] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019900 [kinase binding] GO:0031436 [BRCA1-BARD1 complex] GO:0031441 [negative regulation of mRNA 3'-end processing] GO:0042325 [regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] GO:0045732 [positive regulation of protein catabolic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0046982 [protein heterodimerization activity] GO:0070531 [BRCA1-A complex] GO:0085020 [protein K6-linked ubiquitination]
A0A087X2H0 [Direct mapping] BRCA1-associated RING domain protein 1
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
