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MSTN

GENERAL INFORMATION

Gene name

 MSTN

Gene description

 Myostatin

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Mixed
FANTOM5:Tissue enhanced (cervix, uterine, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct plasma and extracellular positivity with cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB009963
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, skeletal muscle)

GENE INFORMATION

Gene name

 MSTN (HGNC Symbol)

Synonyms

 GDF8

Description

 Myostatin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Nov 2015]

Chromosome

 2

Cytoband

 q32.2

Chromosome location (bp)

 190055697 - 190062729

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138379 (version 83.38)

Entrez gene

 2660

UniProt

 O14793 (UniProt - Evidence at protein level)

neXtProt

 NX_O14793

Antibodypedia

 MSTN antibodies

PROTEIN BROWSER
MSTN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSTN-001
ENSP00000260950
ENST00000260950
O14793 [Direct mapping]
Growth/differentiation factor 8
Q53S46 [Target identity:100%; Query identity:100%]
Growth differentiation factor 8; Myostatin; Putative uncharacterized protein GDF8; cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNA
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007517 [muscle organ development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009408 [response to heat]
GO:0009629 [response to gravity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014732 [skeletal muscle atrophy]
GO:0014741 [negative regulation of muscle hypertrophy]
GO:0014850 [response to muscle activity]
GO:0022602 [ovulation cycle process]
GO:0033574 [response to testosterone]
GO:0033673 [negative regulation of kinase activity]
GO:0040007 [growth]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0043408 [regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0045471 [response to ethanol]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046716 [muscle cell cellular homeostasis]
GO:0048468 [cell development]
GO:0048632 [negative regulation of skeletal muscle tissue growth]
GO:0051384 [response to glucocorticoid]
GO:0051602 [response to electrical stimulus]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060395 [SMAD protein signal transduction]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902723 [negative regulation of skeletal muscle satellite cell proliferation]
GO:1902725 [negative regulation of satellite cell differentiation]
GO:2000818 [negative regulation of myoblast proliferation]
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 375 aa
42.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.