Cell atlas - SSB - The Human Protein Atlas

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SSB

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SSB
Gene description	Sjogren syndrome antigen B (autoantigen La)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017287
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017287	A-431	Nucleoplasm
	HPA017287	U-2 OS	Nucleoplasm
	HPA017287	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	SSB (HGNC Symbol)
Synonyms	La, La/SSB, LARP3
Description	Sjogren syndrome antigen B (autoantigen La) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	169791933 - 169812064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138385 (version 83.38)
Entrez gene	6741
UniProt	P05455 (UniProt - Evidence at protein level)
neXtProt	NX_P05455
Antibodypedia	SSB antibodies

PROTEIN BROWSER

SSB-001	SSB-003	SSB-004	SSB-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSB-001 ENSP00000260956 ENST00000260956	P05455 [Direct mapping] Lupus La protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0000784 [nuclear chromosome, telomeric region] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0006400 [tRNA modification] GO:0008334 [histone mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	408 aa 46.8 kDa	No	0
SSB-003 ENSP00000386636 ENST00000409333	P05455 [Direct mapping] Lupus La protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0000784 [nuclear chromosome, telomeric region] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006400 [tRNA modification] GO:0008334 [histone mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	408 aa 46.8 kDa	No	0
SSB-004 ENSP00000397029 ENST00000422006	E7ERC4 [Direct mapping] Lupus La protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0030529 [ribonucleoprotein complex] Show all	184 aa 21.4 kDa	No	0
SSB-005 ENSP00000396890 ENST00000417292	E9PGX9 [Direct mapping] Lupus La protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0030529 [ribonucleoprotein complex] Show all	120 aa 13.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.