Cell atlas - CHRNA1 - The Human Protein Atlas

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CHRNA1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CHRNA1
Gene description	Cholinergic receptor, nicotinic, alpha 1 (muscle)
Protein class	Disease related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (LHCN-M2, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA071554
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (LHCN-M2, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071554	RH-30	Plasma membrane

GENE INFORMATION
Gene name	CHRNA1 (HGNC Symbol)
Synonyms	CHRNA
Description	Cholinergic receptor, nicotinic, alpha 1 (muscle) (HGNC Symbol)
Entrez gene summary	The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	174747592 - 174764472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138435 (version 83.38)
Entrez gene	1134
UniProt	P02708 (UniProt - Evidence at protein level)
neXtProt	NX_P02708
Antibodypedia	CHRNA1 antibodies

PROTEIN BROWSER

CHRNA1-001	CHRNA1-002	CHRNA1-003	CHRNA1-004	CHRNA1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRNA1-001 ENSP00000261008 ENST00000348749	P02708 [Direct mapping] Acetylcholine receptor subunit alpha Q53SH4 [Target identity:100%; Query identity:100%] Cholinergic receptor, nicotinic, alpha 1 (Muscle), isoform CRA_a; Putative uncharacterized protein CHRNA1; cDNA FLJ77888, highly similar to Human muscle acetylcholine receptor alpha-subunit; cDNA, FLJ96344, Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 1(muscle) (CHRNA1), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Show all	GO:0003009 [skeletal muscle contraction] GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005216 [ion channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0007528 [neuromuscular junction development] GO:0009986 [cell surface] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019228 [neuronal action potential] GO:0030054 [cell junction] GO:0031594 [neuromuscular junction] GO:0034220 [ion transmembrane transport] GO:0035094 [response to nicotine] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045211 [postsynaptic membrane] GO:0046716 [muscle cell cellular homeostasis] GO:0048630 [skeletal muscle tissue growth] GO:0050881 [musculoskeletal movement] GO:0050905 [neuromuscular process] GO:0070050 [neuron cellular homeostasis] GO:0098655 [cation transmembrane transport] Show all	457 aa 51.8 kDa	Yes	4
CHRNA1-002 ENSP00000261007 ENST00000261007	P02708 [Direct mapping] Acetylcholine receptor subunit alpha Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Show all	GO:0003009 [skeletal muscle contraction] GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005216 [ion channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0007528 [neuromuscular junction development] GO:0009986 [cell surface] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0030054 [cell junction] GO:0031594 [neuromuscular junction] GO:0034220 [ion transmembrane transport] GO:0035094 [response to nicotine] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045211 [postsynaptic membrane] GO:0046716 [muscle cell cellular homeostasis] GO:0048630 [skeletal muscle tissue growth] GO:0050881 [musculoskeletal movement] GO:0050905 [neuromuscular process] GO:0070050 [neuron cellular homeostasis] GO:0098655 [cation transmembrane transport] Show all	482 aa 54.5 kDa	Yes	4
CHRNA1-003 ENSP00000387026 ENST00000409542	B8ZZD3 [Direct mapping] Acetylcholine receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	375 aa 42.2 kDa	Yes	4
CHRNA1-004 ENSP00000386684 ENST00000409323	G5E9G9 [Direct mapping] Acetylcholine receptor subunit alpha; Cholinergic receptor, nicotinic, alpha 1 (Muscle), isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0098655 [cation transmembrane transport] Show all	269 aa 30.8 kDa	Yes	1
CHRNA1-005 ENSP00000386611 ENST00000409219	E7ENE5 [Direct mapping] Acetylcholine receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0098655 [cation transmembrane transport] Show all	377 aa 42.8 kDa	Yes	4

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.