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WDR12

CANCER ATLAS

Gene description

 WD repeat domain 12

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036389

GENE INFORMATION

Gene name

 WDR12 (HGNC Symbol)

Synonyms

 FLJ10881, YTM1

Description

 WD repeat domain 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

Chromosome

 2

Cytoband

 q33.2

Chromosome location (bp)

 202874782 - 203014798

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138442 (version 83.38)

Entrez gene

 55759

UniProt

 Q9GZL7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZL7

Antibodypedia

 WDR12 antibodies

PROTEIN BROWSER
WDR12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR12-001
ENSP00000261015
ENST00000261015
Q9GZL7 [Direct mapping]
Ribosome biogenesis protein WDR12
Q53T99 [Target identity:100%; Query identity:100%]
Ribosome biogenesis protein WDR12
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000466 [maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0007219 [Notch signaling pathway]
GO:0008283 [cell proliferation]
GO:0030687 [preribosome, large subunit precursor]
GO:0042273 [ribosomal large subunit biogenesis]
GO:0043021 [ribonucleoprotein complex binding]
GO:0070545 [PeBoW complex]
Show all
 423 aa
47.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.