Cell atlas - SLC40A1 - The Human Protein Atlas

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SLC40A1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SLC40A1
Gene description	Solute carrier family 40 (iron-regulated transporter), member 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (HEL, T-47d, CACO-2, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065634
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, T-47d, CACO-2, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.

Main location

Plasma membrane (supported)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065634	Hep G2	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA065634	RT4	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA065634	U-2 OS	Plasma membrane
	HPA065634	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SLC40A1 (HGNC Symbol)
Synonyms	FPN1, HFE4, IREG1, MTP1, SLC11A3
Description	Solute carrier family 40 (iron-regulated transporter), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	189560579 - 189583758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138449 (version 83.38)
Entrez gene	30061
UniProt	Q9NP59 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP59
Antibodypedia	SLC40A1 antibodies

PROTEIN BROWSER

SLC40A1-001	SLC40A1-002	SLC40A1-003	SLC40A1-004	SLC40A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC40A1-001 ENSP00000261024 ENST00000261024	Q9NP59 [Direct mapping] Solute carrier family 40 member 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002260 [lymphocyte homeostasis] GO:0003158 [endothelium development] GO:0004872 [receptor activity] GO:0005381 [iron ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008021 [synaptic vesicle] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0017046 [peptide hormone binding] GO:0034395 [regulation of transcription from RNA polymerase II promoter in response to iron] GO:0034755 [iron ion transmembrane transport] GO:0043066 [negative regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048536 [spleen development] GO:0055072 [iron ion homeostasis] GO:0055085 [transmembrane transport] GO:0060345 [spleen trabecula formation] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0097689 [iron channel activity] GO:1903988 [ferrous iron export] Show all	571 aa 62.5 kDa	No	>9
SLC40A1-002 ENSP00000390005 ENST00000427241	E7ES28 [Direct mapping] Solute carrier family 40 member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005381 [iron ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034755 [iron ion transmembrane transport] Show all	200 aa 21.9 kDa	No	3
SLC40A1-003 ENSP00000392730 ENST00000427419	Q4PNE6 [Direct mapping] Ferroportin 1 variant I; Ferroportin 1 variant IIA; Ferroportin 1 variant IIB; Solute carrier family 40 member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
SLC40A1-004 ENSP00000413549 ENST00000455320	E7EQF8 [Direct mapping] Solute carrier family 40 member 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005381 [iron ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034755 [iron ion transmembrane transport] Show all	55 aa 6.2 kDa	No	0
SLC40A1-005 ENSP00000396134 ENST00000440626	Q4PNE6 [Direct mapping] Ferroportin 1 variant I; Ferroportin 1 variant IIA; Ferroportin 1 variant IIB; Solute carrier family 40 member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.