Cell atlas - PARP9 - The Human Protein Atlas

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PARP9

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PARP9
Gene description	Poly (ADP-ribose) polymerase family, member 9
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitochondria.
RNA cell category	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+ SV40 Large T+)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (supported)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA066708
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+ SV40 Large T+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitochondria.

Main location

Nucleoplasm (supported), Cytosol (supported)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066708	RH-30	Nucleoplasm
	HPA066708	RH-30	Cytosol
	HPA066708	SK-MEL-30	Nucleoplasm
	HPA066708	SK-MEL-30	Cytosol
	HPA066708	U-2 OS	Mitochondria
	HPA066708	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PARP9 (HGNC Symbol)
Synonyms	BAL, BAL1
Description	Poly (ADP-ribose) polymerase family, member 9 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	122527924 - 122564577
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138496 (version 83.38)
Entrez gene	83666
UniProt	Q8IXQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXQ6
Antibodypedia	PARP9 antibodies

PROTEIN BROWSER

PARP9-001	PARP9-002	PARP9-003	PARP9-004	PARP9-005	PARP9-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP9-001 ENSP00000353512 ENST00000360356	Q8IXQ6 [Direct mapping] Poly [ADP-ribose] polymerase 9 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006302 [double-strand break repair] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0060330 [regulation of response to interferon-gamma] Show all	854 aa 96.3 kDa	No	0
PARP9-002 ENSP00000419506 ENST00000477522	Q8IXQ6 [Direct mapping] Poly [ADP-ribose] polymerase 9 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006302 [double-strand break repair] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0060330 [regulation of response to interferon-gamma] Show all	819 aa 92.3 kDa	No	0
PARP9-003 ENSP00000418894 ENST00000462315	Q8IXQ6 [Direct mapping] Poly [ADP-ribose] polymerase 9 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006302 [double-strand break repair] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0060330 [regulation of response to interferon-gamma] Show all	710 aa 80.3 kDa	No	0
PARP9-004 ENSP00000417664 ENST00000492382	G5E9U8 [Direct mapping] Poly (ADP-ribose) polymerase family, member 9, isoform CRA_b; Poly [ADP-ribose] polymerase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0008152 [metabolic process] Show all	399 aa 45.7 kDa	No	0
PARP9-005 ENSP00000419001 ENST00000471785	Q8IXQ6 [Direct mapping] Poly [ADP-ribose] polymerase 9 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006302 [double-strand break repair] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0060330 [regulation of response to interferon-gamma] Show all	819 aa 92.3 kDa	No	0
PARP9-007 ENSP00000419626 ENST00000466126	C9K0E5 [Direct mapping] Poly [ADP-ribose] polymerase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.