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USP8

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GENERAL INFORMATION

Gene name

 USP8

Gene description

 Ubiquitin specific peptidase 8

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050215
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol.

Main location

 Golgi apparatus (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050215 A-431 Nucleoplasm
Golgi apparatus
HPA050215 U-2 OS Golgi apparatus
HPA050215 U-251 MG Golgi apparatus
Cytosol

GENE INFORMATION

Gene name

 USP8 (HGNC Symbol)

Synonyms

 HumORF8, KIAA0055, SPG59, UBPY

Description

 Ubiquitin specific peptidase 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 50424380 - 50514419

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138592 (version 83.38)

Entrez gene

 9101

UniProt

 P40818 (UniProt - Evidence at protein level)

neXtProt

 NX_P40818

Antibodypedia

 USP8 antibodies

PROTEIN BROWSER
USP8-001
USP8-002
USP8-003
USP8-008
USP8-011
USP8-017
USP8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP8-001
ENSP00000379721
ENST00000396444
P40818 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
A0A024R5S4 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0001669 [acrosomal vesicle]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007032 [endosome organization]
GO:0007265 [Ras protein signal transduction]
GO:0008283 [cell proliferation]
GO:0016579 [protein deubiquitination]
GO:0017124 [SH3 domain binding]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030496 [midbody]
GO:0031313 [extrinsic component of endosome membrane]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 1118 aa
127.5 kDa 		No 0
USP8-002
ENSP00000412682
ENST00000425032
P40818 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007032 [endosome organization]
GO:0008283 [cell proliferation]
GO:0016579 [protein deubiquitination]
GO:0017124 [SH3 domain binding]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030496 [midbody]
GO:0031313 [extrinsic component of endosome membrane]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 1012 aa
115.1 kDa 		No 0
USP8-003
ENSP00000302239
ENST00000307179
P40818 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
A0A024R5S4 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007032 [endosome organization]
GO:0008283 [cell proliferation]
GO:0016579 [protein deubiquitination]
GO:0017124 [SH3 domain binding]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030496 [midbody]
GO:0031313 [extrinsic component of endosome membrane]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 1118 aa
127.5 kDa 		No 0
USP8-008
ENSP00000453206
ENST00000560297
H0YLH2 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031313 [extrinsic component of endosome membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 96 aa
11.2 kDa 		No 0
USP8-011
ENSP00000453427
ENST00000560982
H0YM17 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031313 [extrinsic component of endosome membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 73 aa
8.5 kDa 		No 0
USP8-017
ENSP00000454059
ENST00000558091
H0YNL5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031313 [extrinsic component of endosome membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 135 aa
15.9 kDa 		No 0
USP8-201
ENSP00000485810
ENST00000625664
H0YLS3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031313 [extrinsic component of endosome membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 62 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.