Expression of GLCE in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glucuronic acid epimerase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA040481	HPA048216

GENE INFORMATION
Gene name	GLCE (HGNC Symbol)
Synonyms	HSEPI, KIAA0836
Description	Glucuronic acid epimerase (HGNC Symbol)
Entrez gene summary	Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]
Chromosome	15
Cytoband	q23
Chromosome location (bp)	69160584 - 69272217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138604 (version 83.38)
Entrez gene	26035
UniProt	O94923 (UniProt - Evidence at protein level)
neXtProt	NX_O94923
Antibodypedia	GLCE antibodies

PROTEIN BROWSER

GLCE-001	GLCE-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLCE-001 ENSP00000454092 ENST00000559420	H0YNP1 [Direct mapping] D-glucuronyl C5-epimerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0016857 [racemase and epimerase activity, acting on carbohydrates and derivatives] Show all	553 aa 62.9 kDa	No	0
GLCE-201 ENSP00000261858 ENST00000261858	O94923 [Direct mapping] D-glucuronyl C5-epimerase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0016857 [racemase and epimerase activity, acting on carbohydrates and derivatives] GO:0030203 [glycosaminoglycan metabolic process] GO:0030210 [heparin biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047464 [heparosan-N-sulfate-glucuronate 5-epimerase activity] GO:0050379 [UDP-glucuronate 5'-epimerase activity] Show all	617 aa 70.1 kDa	Yes	0