Expression of PPCDC in cancer - Summary

CANCER ATLAS

Gene description

Phosphopantothenoylcysteine decarboxylase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045667

GENE INFORMATION
Gene name	PPCDC (HGNC Symbol)
Synonyms	FLJ14585, MDS018
Description	Phosphopantothenoylcysteine decarboxylase (HGNC Symbol)
Entrez gene summary	Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q24.2
Chromosome location (bp)	75023555 - 75117462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138621 (version 83.38)
Entrez gene	60490
UniProt	Q96CD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CD2
Antibodypedia	PPCDC antibodies

PROTEIN BROWSER

PPCDC-001	PPCDC-002	PPCDC-003	PPCDC-005	PPCDC-006	PPCDC-007	PPCDC-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPCDC-001 ENSP00000343190 ENST00000342932	Q96CD2 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004633 [phosphopantothenoylcysteine decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0044281 [small molecule metabolic process] Show all	204 aa 22.4 kDa	No	0
PPCDC-002 ENSP00000457490 ENST00000563393	H3BU63 [Direct mapping] Phosphopantothenoylcysteine decarboxylase; Phosphopantothenoylcysteine decarboxylase, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	81 aa 9 kDa	No	0
PPCDC-003 ENSP00000455499 ENST00000569562	H3BPW5 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	64 aa 7 kDa	No	0
PPCDC-005 ENSP00000456665 ENST00000564923	H3BSE3 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	129 aa 14 kDa	No	0
PPCDC-006 ENSP00000456353 ENST00000567336	H3BRQ0 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	172 aa 18.7 kDa	No	0
PPCDC-007 ENSP00000455691 ENST00000568649	H3BQB0 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	161 aa 17.6 kDa	No	0
PPCDC-008 ENSP00000457446 ENST00000562095	H3BU34 [Direct mapping] Phosphopantothenoylcysteine decarboxylase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	62 aa 6.6 kDa	No	0