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ARHGAP24

GENERAL INFORMATION

Gene name

 ARHGAP24

Gene description

 Rho GTPase activating protein 24

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, including lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA014288
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARHGAP24 (HGNC Symbol)

Synonyms

 DKFZP564B1162, FilGAP, FLJ33877

Description

 Rho GTPase activating protein 24 (HGNC Symbol)

Entrez gene summary

 ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

Chromosome

 4

Cytoband

Chromosome location (bp)

 85475114 - 86002670

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138639 (version 83.38)

Entrez gene

 83478

UniProt

 Q8N264 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N264

Antibodypedia

 ARHGAP24 antibodies

PROTEIN BROWSER
ARHGAP24-001
ARHGAP24-002
ARHGAP24-003
ARHGAP24-005
ARHGAP24-006
ARHGAP24-009
ARHGAP24-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP24-001
ENSP00000378611
ENST00000395184
Q8N264 [Direct mapping]
Rho GTPase-activating protein 24
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0035021 [negative regulation of Rac protein signal transduction]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0042995 [cell projection]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0090630 [activation of GTPase activity]
GO:1900028 [negative regulation of ruffle assembly]
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 748 aa
84.3 kDa 		No 0
ARHGAP24-002
ENSP00000264343
ENST00000264343
Q8N264 [Direct mapping]
Rho GTPase-activating protein 24
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0042995 [cell projection]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 655 aa
73.4 kDa 		No 0
ARHGAP24-003
ENSP00000423206
ENST00000503995
Q8N264 [Direct mapping]
Rho GTPase-activating protein 24
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0042995 [cell projection]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 246 aa
28.2 kDa 		No 0
ARHGAP24-005
ENSP00000378610
ENST00000395183
Q8N264 [Direct mapping]
Rho GTPase-activating protein 24
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030154 [cell differentiation]
GO:0042995 [cell projection]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 653 aa
73.3 kDa 		No 0
ARHGAP24-006
ENSP00000425589
ENST00000514229
D6RCP5 [Direct mapping]
Rho GTPase-activating protein 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
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 622 aa
69.5 kDa 		No 0
ARHGAP24-009
ENSP00000426105
ENST00000512201
D6RHH1 [Direct mapping]
Rho GTPase-activating protein 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 82 aa
9.6 kDa 		No 0
ARHGAP24-010
ENSP00000424256
ENST00000509300
D6RBC2 [Direct mapping]
Rho GTPase-activating protein 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 118 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.