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Most of the malignant tissues displayed weak cytoplasmic positivity or were negative. Several cases of renal and liver cancers along with a few cases of breast, skin and pancreatic cancers exhibited moderate staining.
GENE INFORMATION
Gene name
HERC3 (HGNC Symbol)
Synonyms
KIAA0032
Description
HECT and RLD domain containing E3 ubiquitin protein ligase 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)