Expression of HERC6 in cancer - Summary

CANCER ATLAS

Gene description

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035846

GENE INFORMATION
Gene name	HERC6 (HGNC Symbol)
Synonyms	FLJ20637
Description	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (HGNC Symbol)
Entrez gene summary	HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	88378739 - 88443111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138642 (version 83.38)
Entrez gene	55008
UniProt	Q8IVU3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IVU3
Antibodypedia	HERC6 antibodies

PROTEIN BROWSER

HERC6-001	HERC6-003	HERC6-006	HERC6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERC6-001 ENSP00000264346 ENST00000264346	Q8IVU3 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002244 [hematopoietic progenitor cell differentiation] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	1022 aa 115.1 kDa	No	1
HERC6-003 ENSP00000369617 ENST00000380265	Q8IVU3 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	986 aa 111.1 kDa	No	1
HERC6-006 ENSP00000425060 ENST00000502870	H0Y9U0 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 19.5 kDa	No	0
HERC6-201 ENSP00000273960 ENST00000273960	A0A0B4J1R3 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		322 aa 34.5 kDa	No	0