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Testicular seminomas showed moderate to strong cytoplasmic positivity. A few ovarian cancers and hepatocellular carcinomas exhibited weak to moderate staining. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
HERC5 (HGNC Symbol)
Synonyms
CEB1
Description
HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HGNC Symbol)
Entrez gene summary
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]