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COPS4

CANCER ATLAS

Gene description

 COP9 signalosome subunit 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036894

GENE INFORMATION

Gene name

 COPS4 (HGNC Symbol)

Synonyms

 CSN4

Description

 COP9 signalosome subunit 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 4

Cytoband

 q21.22

Chromosome location (bp)

 83034447 - 83075818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138663 (version 83.38)

Entrez gene

 51138

UniProt

 Q9BT78 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BT78

Antibodypedia

 COPS4 antibodies

PROTEIN BROWSER
COPS4-001
COPS4-002
COPS4-003
COPS4-004
COPS4-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPS4-001
ENSP00000264389
ENST00000264389
Q9BT78 [Direct mapping]
COP9 signalosome complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000338 [protein deneddylation]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0008021 [synaptic vesicle]
GO:0008180 [COP9 signalosome]
GO:0010388 [cullin deneddylation]
GO:0019784 [NEDD8-specific protease activity]
GO:0030054 [cell junction]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 406 aa
46.3 kDa 		No 0
COPS4-002
ENSP00000425976
ENST00000509093
Q9BT78 [Direct mapping]
COP9 signalosome complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000338 [protein deneddylation]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0008021 [synaptic vesicle]
GO:0008180 [COP9 signalosome]
GO:0010388 [cullin deneddylation]
GO:0019784 [NEDD8-specific protease activity]
GO:0030054 [cell junction]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 352 aa
40.2 kDa 		No 0
COPS4-003
ENSP00000424791
ENST00000503682
D6RFN0 [Direct mapping]
COP9 signalosome complex subunit 4
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0030054 [cell junction]
Show all
 438 aa
49.7 kDa 		No 0
COPS4-004
ENSP00000424655
ENST00000511653
D6RAX7 [Direct mapping]
COP9 signalosome complex subunit 4
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
Show all
 420 aa
47.7 kDa 		No 0
COPS4-011
ENSP00000425486
ENST00000509317
D6RD63 [Direct mapping]
COP9 signalosome complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
Show all
 275 aa
31.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.