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PRKG2

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GENERAL INFORMATION

Gene name

 PRKG2

Gene description

 Protein kinase, cGMP-dependent, type II

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HEL, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PRKG2 (HGNC Symbol)

Synonyms

 cGKII, PRKGR2

Description

 Protein kinase, cGMP-dependent, type II (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 4

Cytoband

 q21.21

Chromosome location (bp)

 81087370 - 81215117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138669 (version 83.38)

Entrez gene

 5593

UniProt

 Q13237 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13237

Antibodypedia

 PRKG2 antibodies

PROTEIN BROWSER
PRKG2-001
PRKG2-005
PRKG2-201
PRKG2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKG2-001
ENSP00000378945
ENST00000395578
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 762 aa
87.4 kDa 		No 0
PRKG2-005
ENSP00000486129
ENST00000628926
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 733 aa
84.4 kDa 		No 0
PRKG2-201
ENSP00000264399
ENST00000264399
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007623 [circadian rhythm]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0031965 [nuclear membrane]
GO:0032922 [circadian regulation of gene expression]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0072661 [protein targeting to plasma membrane]
Show all
 762 aa
87.4 kDa 		No 0
PRKG2-202
ENSP00000439967
ENST00000545647
B7ZA25 [Direct mapping]
cDNA, FLJ79039, highly similar to cGMP-dependent protein kinase 2 (EC 2.7.11.12); cGMP-dependent protein kinase 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 342 aa
39.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.